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KMID : 0861020110260030083
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Korea Journal of Herbology
2011 Volume.26 No. 3 p.83 ~ p.90
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Study on Antiangiogenic Effect of Black Ginseng Radix
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Song Gyu-Yong
Cheong Kyu-Jin
Shin Young-Jin
Lee Gye-Won
Lee Sook-Young
Seo Young-Bae
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Abstract
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Objectives:This study was performed to investigate the influence of black ginseng radix extracts (BG) and ginsenoside Rg3, Rg5 on basic fibroblast growth factor (bFGF) induced proliferation, migration and capillary tubule-like formation of human umbilical vein endothelial cells (HUVECs).
Methods:HUVECs were cultured with BG and ginsenoside Rg3, Rg5 at different concentrations (60, 125, 250, 500, 1,000㎍/㎖) for 2 day In the presence of bFGF, respectively. XTT was used to detect the proliferation. Migration and tube formations were examined to detect the antiangiogenesis. Also, the chick embryo chorioallantoic membrane (CAM) assay was performed to detect the antiangiogenesis.
Results: BG and ginsenoside Rg3, Rg5 significantly inhibited bFGF-induced endothelial cell proliferation and migration in a dose-dependent manner. Tube formation in bFGF-induced HUVECs were suppressed by BG and ginsenoside Rg3, Rg5. Moreover, BG and ginsenoside Rg3, Rg5 (30-/egg) inhibited new blood vessel formation on the growing CAM.
Conclusion:Based on the present results, it can be suggested that BG has a potential chemopreventive agent via antiangiogenesis.
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KEYWORD
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Black ginsneng, antiangiogesesis, ginsenoside Rg3, Rg5, CAM
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